Professor Susan Brooks

PhD

Professor of Cell Biology and Director of Researcher Development

School of Biological and Medical Sciences

sbrooks@brookes.ac.uk

Research

Glycobiology and cancer

Groups

Cancer biology – glycobiology and cell signalling through extracellular vesicles

Publications

McGinness AJ, Brooks SA, Strasser R Schoberer J, Kriechbaumer V, Suborganellar resolution imaging for the localisation of human glycosylation enzymes in tobacco Golgi bodies
Journal of Microscopy [online first] (2024) ISSN: 0022-2720 eISSN: 1365-2818 Suborganellar resolution imaging for the localisation of human glycosylation enzymes in tobacco Golgi bodies Open Access version on RADAR
Brooks SA, Lectins as versatile tools to explore cellular glycosylation
European Journal of Histochemistry 68 (1) (2024) ISSN: 1121-760X Lectins as versatile tools to explore cellular glycosylation Open Access version on RADAR
Al-Abedi R, Cagataya ST, Mayah A, Brooks SA, Kadhim M, Therapeutic fractional doses of ionizing radiation promote epithelial-mesenchymal transition, enhanced invasiveness and altered glycosylation in MCF-7 breast cancer cells
Genome Integrity 14 (1) (2023)
Beaman E-M, Carter DRF, Brooks SA, GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?
Glycobiology 32 (7) (2022) pp.556-579 ISSN: 0959-6658 eISSN: 1460-2423 GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)? Open Access version on RADAR
Pink RC, Beaman E, Samuel P, Brooks SA, Carter DRF, Utilising extracellular vesicles for early cancer diagnostics: benefits, challenges and recommendations for the future
British Journal of Cancer 126 (2022) pp.323-333 ISSN: 0007-0920 eISSN: 1532-1827 Utilising extracellular vesicles for early cancer diagnostics: benefits, challenges and recommendations for the future Open Access version on RADAR
Al-Abedi R, Tuncay Cagatay S, Mayah A, Brooks SA, Kadhim M, Ionising Radiation Promotes Invasive Potential of Breast Cancer Cells: The Role of Exosomes in the Process
International Journal of Molecular Sciences 22 (21) (2021) ISSN: 1661-6596 eISSN: 1422-0067 Ionising Radiation Promotes Invasive Potential of Breast Cancer Cells: The Role of Exosomes in the Process Open Access version on RADAR
Pantazi P, Carollo E, Carter DRF, Brooks SA, A practical toolkit to study aspects of the metastatic cascade in vitro
Acta Histochemica: Research and Methods in Cell and Tissue Biology 122 (8) (2020) ISSN: 0065-1281 A practical toolkit to study aspects of the metastatic cascade in vitro Open Access version on RADAR
Kadhim MA, Mayah A, Brooks SA , Does direct and indirect exposure to ionising radiation influence metastatic potential of breast cancer cells?
Cancers 12 (1) (2020) ISSN: 2072-6694 eISSN: 2072-6694 Does direct and indirect exposure to ionising radiation influence metastatic potential of breast cancer cells? Open Access version on RADAR
Kadhim MA, Mayah A, Brooks SA, Does Direct and Indirect Exposure to Ionising Radiation Influence the Metastatic Potential of Breast Cancer Cells
Cancers 12 (1) (2020) ISSN: 2072-6694 eISSN: 2072-6694 Does Direct and Indirect Exposure to Ionising Radiation Influence the Metastatic Potential of Breast Cancer Cells Open Access version on RADAR
Carollo E, Paris B, Samuel P, Pantazi P, Bartelli TF, Dias-Neto E, Brooks SA, Pink RC, Carter DRF, Detecting Ovarian Cancer Using Extracellular Vesicles: Progress and Possibilities
Biochemical Society Transactions 47 (1) (2019) pp.295-304 ISSN: 0300-5127 eISSN: 1470-8752 Detecting Ovarian Cancer Using Extracellular Vesicles: Progress and Possibilities Open Access version on RADAR
Parameswaran R, Tan WB, Nga ME, Soon GST, Ngiam KY, Brooks SA, Sadler GP, Mihai R, Binding of aberrant glycoproteins recognizable by Helix pomatia agglutinin in adrenal cancers
BJS Open 2 (5) (2018) pp.353-359 ISSN: 2474-9842 Binding of aberrant glycoproteins recognizable by Helix pomatia agglutinin in adrenal cancers Open Access version on RADAR
Samuel P, Mulcahy LA, Furlong F, McCarthy HO, Brooks S, Fabbri M, Pink RC, Carter DRF, Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells.
Philosophical Transactions of the Royal Society B: Biological Sciences 373 (1737) (2017) ISSN: 0962-8436 eISSN: 1471-2970 Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells. Open Access version on RADAR
Awolaran G, Brooks SA, Lavender V, Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence
The Breast 30 (2016) pp.156-171 ISSN: 0960-9776 eISSN: 1532-3080 Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence Open Access version on RADAR
Bapu D, Runions J, Kadhim M, Brooks SA, N-acetylgalactosamine glycans function in cancer cell adhesion to endothelial cells: a role for truncated O-glycans in metastatic mechanisms.
Cancer Letters 375 (2) (2016) pp.367-374 ISSN: 0304-3835 eISSN: 1872-7980 N-acetylgalactosamine glycans function in cancer cell adhesion to endothelial cells: a role for truncated O-glycans in metastatic mechanisms. Open Access version on RADAR
Samuel P, Pink RC, Brooks SA, Carter DR, miRNAs and ovarian cancer: a miRiad of mechanisms to induce cisplatin drug resistance.
Expert Review of Anticancer Therapy 16 (1) (2016) pp.57-70 ISSN: 1473-7140 eISSN: 1744-8328
Samuel P, Pink RC, Caley DP, Stevenson Currie JM, Brooks SA, Carter DRF, Over-expression of miR-31 or loss of KCNMA1 leads to increased cisplatin-resistance in ovarian cancer cells
Tumor Biology 37 (2) (2015) pp.2565-2573 ISSN: 1010-4283 eISSN: 1423-0380
Pink RC, Samuel P, Massa D, Caley DP, Brooks SA, Carter DRF, The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells
Gynecologic Oncology 137 (1) (2015) pp.143-151 ISSN: 0090-8258
Beaman EM, Brooks SA, The extended ppGalNAc-T family and their functional involvement in the metastatic cascade
Histology and Histopathology 29 (3) (2014) pp.293-304 ISSN: 0213-3911
Brooks SA, Basic immunocytochemistry for light microscopy
Methods in Molecular Biology 878 (2012) pp.1-30 ISSN: 1064-3745
Brooks S, Hall D, Lectin histochemistry to detect altered glycosylation in cells and tissues
Methods in Molecular Biology 878 (2012) pp.31-50 ISSN: 1064-3745
Parameswaran R, Sadler G, Brooks S, Helix pomatia Agglutinin Binding Glycoproteins in Thyroid Tumors
World Journal of Surgery 35 (10) (2011) pp.2219-2227 ISSN: 0364-2313 eISSN: 1432-2323
Ayers L, Kohler M, Harrison P, Sargent I, Dragovic R, Schaap M, Nieuwland R, Brooks S, Measurement of circulating cell-derived microparticles by flow cytometry: Sources of variability within the assay
Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis 127 (4) (2011) pp.370-377 ISSN: 0049-3848
Brooks S, Lomax-Browne H, Carter T, Kinch C, Hall D, Molecular interactions in cancer cell metastasis
Acta Histochemica: Research and Methods in Cell and Tissue Biology 112 (1) (2010) pp.3-25 ISSN: 0065-1281
Parameswaran R, Brooks S, Sadler G, Molecular pathogenesis of follicular cell derived thyroid cancers
International Journal of Surgery 8 (3) (2010) pp.186-193 ISSN: 1743-9191
Brooks S, Strategies for analysis of the glycosylation of proteins: current status and future perspectives
Molecular Biotechnology 43 (1) (2009) pp.76-88 ISSN: 1073-6085
Brooks SA, Strategies for analysis of the glycosylation of proteins: current status and future perspectives
Molecular Biotechnology 43 (1) (2009) pp.76-88 ISSN: 1073-6085
Brooks S, Carter T, Royle L, Harvey D, Fry S, Kinch C, Dwek R, Rudd P, Altered glycosylation of proteins in cancer: What is the potential for new anti-tumour strategies
Anti-Cancer Agents in Medicinal Chemistry 8 (1) (2008) pp.2-21 ISSN: 1871-5206
Brooks S, Glycosylation in diverse cell systems : similarities, differences and challenges
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 150 (3) (2008) pp.S163-S163 ISSN: 1095-6433 eISSN: 1531-4332
Brooks SA, Carter TM, Bennett EP, Clausen H, Mandel U, Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer
Acta Histochemica: Research and Methods in Cell and Tissue Biology 109 (4) (2007) pp.273-284 ISSN: 0065-1281
Lomax-Browne H, Brooks S, Kinch C, Kieda C, Interactions between cancer cell glycans and endothelial cells during adhesion and transmigration events in metastasis
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 146 (4) (2007) pp.S191-S192 ISSN: 1095-6433 eISSN: 1531-4332
Valentiner U, Hall DMS, Brooks SA, Schumacher U, HPA binding and metastasis formation of human breast cancer cell lines transplanted into severe combined immunodeficient (scid) mice
Cancer Letters 219 (2) (2005) pp.233-242 ISSN: 0304-3835 eISSN: 1872-7980
Schumacher U, Brooks SA, Mester, J, The lectin Helix pomatia agglutinin as a marker of metastases--clinical and experimental studies
Anticancer Research 25 (2005) pp.1829-1830 ISSN: 0250-7005 eISSN: 1791-7530
Brooks SA, Appropriate glycosylation of recombinant proteins for human use - Implications of choice of expression system
Molecular Biotechnology 28 (3) (2004) pp.241-255 ISSN: 1073-6085
Brooks SA, Wilkinson D, Validation of a simple avidin-biotin detection method for Helix pomatia lectin (HPA) binding as a prognostic marker in cancer
Acta Histochemica: Research and Methods in Cell and Tissue Biology 105 (3) (2003) pp.205-212 ISSN: 0065-1281
Brooks SA, Hall DMS, Investigations into the potential role of aberrant N- acetylgalactosamine glycans in tumour cell interactions with basement membrane components
Clinical and Experimental Metastasis 19 (6) (2002) pp.487-493 ISSN: 0262-0898 eISSN: 1473-7276
Brooks SA, Hall DMS, Buley I, GaINAc glycoprotein expression by breast cell lines, primary breast cancer and normal breast epithelial membrane
British Journal of Cancer 85 (2001) pp.1014-1022 ISSN: 0007-0920 eISSN: 1532-1827
Dwek MV, Ross HA, Streets AJ, Brooks SA, Adam E, Titcomb A, Woodside JV, Schumacher U, Leathem AJ, Helix pomatia agglutinin lectin-binding oligosaccharides of aggressive breast cancer
International Journal of Cancer 95 (2001) pp.79-85 ISSN: 0020-7136 eISSN: 1097-0215
Brooks SA, Carter TM, N-acetylgalactosamine, N-acetylglucosamine and sialic acid expression in primary breast cancers
Acta Histochemica: Research and Methods in Cell and Tissue Biology 103 (1) (2001) pp.37-51 ISSN: 0065-1281
Brooks SA, The involvement of Helix pomatia lectin (HPA) binding N- acetylgalactosamine glycans in cancer progression
Histology and Histopathology 15 (2000) pp.143-158 ISSN: 0213-3911 eISSN: 1699-5848
Holloway Z, Carter TN, Groome N, Evans L, Brooks SA, Expression of Inhibin, Activin and Follistatin By Breast Cancer - An Immunohistochemical Study Using Anti-peptide Monoclonal Antibodies
The Journal of Pathology 187 (1999) pp.24A-24A ISSN: 0022-3417 eISSN: 1096-9896

Hopkins S, Brooks SA, Yeung A, Mentoring to empower researchers ,
Sage (2020) ISBN: 9781526465122
Brooks S, (ed.), Metastasis research protocols. Vol. 2, Cell behaviour in vitro and in vivo ,
Humana Press (2014) eISSN: 1064-3745 ISBN: 9781461482437 eISBN: 9781461482444
Brooks S, (ed.), Metastasis research protocols. Vol. 1, Analysis of cells and tissues ,
Humana Press (2013) ISBN: 9780896036109 eISBN: 9781592591367
Brooks SA, Harris A, (ed.), Breast cancer research protocols ,
Humana Press (2005) ISBN: 9781588291912 eISBN: 9781592599691

Brooks SA, Lectin histochemistry: historical perspectives, state of the art and future directions
in Carlo Pellicciari, Marco Biggiogera, and Manuela Malatesta (ed.), Histochemistry of Single Molecules: Methods and Protocols, Second Edition, Springer (2022) eISSN: 1940-6029 ISBN: 9781071626740 eISBN: 9781071626757 Lectin histochemistry: historical perspectives, state of the art and future directions Open Access version on RADAR
Beaman E-M, Carter DRF, Brooks SA, Isolation of viable glycosylation-specific cell populations for further in vitro or in vivo analysis using lectin-coated magnetic beads.
in Pellicciari C, Biggiogera M (ed.), Histochemistry of Single Molecules, Springer (2017) ISBN: 9781493967872 eISBN: 9781493967889
Brooks SA, Lectin histochemistry: historical perspectives, state of the art and the future
in Pellicciari C, Biggiogera M (ed.), Histochemistry of Single Molecules, Springer (2017) ISBN: 9781493967872 eISBN: 9781493967889
Dwek MV, Brooks SA, Structure and function of N-glycans
in Michael J. Dunn, Lynn B. Jorde, Peter F.R. Little, Shankar Subramaniam (ed.), Encyclopaedia of genomics, proteomics and bioinformatics, Wiley (2005) ISBN: 9780470849743

Brooks S, Human N- and O-linked protein glycosylation : An overview
150 (3) (2008) pp.S162-S162

Lomax-Browne H, Brooks S, Interactions between cancer cell glycans and endothelial cells during Adhesion and transmigration events in metastasis ,
(2008)

Professor Susan Brooks

Research

Groups

Publications

Journal articles