Dr Laura Gathercole

Senior Lecturer in Human Physiology

School of Biological and Medical Sciences

Research

Groups

Bile Acid and Steroid Hormone Metabolism in Disease

Publications

Morgan SA, Gathercole LL, Hassan-Smith ZK, Tomlinson J, Stewart PM, Lavery GG, 11β-HSD1 contributes to age-related metabolic decline in male mice
Journal of Endocrinology 255 (3) (2022) pp.117-129 ISSN: 0022-0795 eISSN: 1479-6805
Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW, AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
Journal of Molecular Endocrinology 253 (3) (2022) pp.97-113 ISSN: 0952-5041 eISSN: 1479-6813
Hazlehurst JM, Lim TR, Charlton C, Miller JJ, Gathercole LL, Cornfield T, Nikolaou N, Harris SE, Moolla A, Othonos N, Heather LC, Marjot T, Tyler DJ, Carr C, Hodson L, McKeating J, Tomlinson JW, Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents
Metabolism Open 14 (2022) ISSN: 2589-9368
Appanna N, Gibson H, Gangitano E, Dempster NJ, Morris K, George S, Arvaniti A, Gathercole LL, Keevil B, Penning TM, Storbeck KH, Tomlinson JW, Nikolaou N, Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
Journal of Molecular Endocrinology 66 (3) (2021) pp.181-194 ISSN: 0952-5041 eISSN: 1479-6813
Harris SE, Poolman TM, Arvaniti A, Cox RD, Gathercole LL, Tomlinson JW, The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
American Journal of Physiology - Gastrointestinal and Liver Physiology 319 (3) (2020) pp.G345-G360 ISSN: 0193-1857 eISSN: 1522-1547
Nikolaou N, Arvaniti A, Appanna N, Sharp A, Hughes BA, Digweed D, Whitaker MJ, Ross R, Arlt W, Penning TM, Morris K, George S, Keevil BG, Hodson L, Gathercole LL, Tomlinson JW, Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
Journal of Endocrinology 245 (2) (2020) pp.207-218 ISSN: 0022-0795 eISSN: 1479-6805
Nikolaou N, Gathercole L, Marchand L, Althari S, Dempster N, Green C, van de Bunt M, McNeil C, Arvaniti A, Hughes B, Sgromo B, Gillies R, Marschall H, Penning P, Ryan J, Arlt W, Hodson L, Tomlinson J, AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
Metabolism 99 (2019) pp.67-80 ISSN: 0026-0495 AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease Open Access version on RADAR
Chen M, Wangtrakuldee P, Zang T, Duan L, Gathercole LL, Tomlinson JW, Penning TM, Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid
Chemico-Biological Interactions: A journal of molecular, cellular and biochemical toxicology 305 (2019) pp.163-170 ISSN: 0009-2797 eISSN: 1872-7786
Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, Oppermann U, Penning TM, Arlt W, Hodson L, Tomlinson JW, AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
The Journal of Steroid Biochemistry and Molecular Biology 189 (2019) pp.218-227 ISSN: 0960-0760 eISSN: 1879-1220
Crowley RK, Woods CP, Hughes BA, Gray J, McCarthy T, Taylor AE, Gathercole LL, Shackleton CHL, Crabtree N, Arlt W, Stewart PM, Tomlinson JW, Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study.
Clinical Endocrinology 91 (1) (2019) pp.72-81 ISSN: 0300-0664 eISSN: 1365-2265 Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study. Open Access version on RADAR
Woods CP, Crowley RK, Gathercole LL, Hughes B, Gray J, McCarthy T, Crabtree N, Stewart PM, Tomlinson JW, Changes in adipose tissue gene expression profile and fat mass are associated with deteriorating glucose tolerance
Irish Journal of Medical Science 185 (Suppl 7) (2016) pp.372-372 ISSN: 0021-1265 eISSN: 1863-4362
Larner DP, Morgan SA, Gathercole LL, Doig CL, Guest P, Weston C, Hazeldine J, Tomlinson JW, Stewart PM, Lavery GG, Male 11 beta-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease
Endocrinology 157 (9) (2016) pp.3493-3504 ISSN: 0013-7227 eISSN: 1945-7170
Gathercole LL, Hazlehurst JM, Armstrong MJ, Crowley R, Boocock S, O'Reilly MW, Round M, Brown R, Bolton S, Cramb R, Newsome PN, Semple RK, Paisey R, Tomlinson JW, Geberhiwot T, Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alstrom syndrome
Liver International 36 (11) (2016) pp.1704-1712 ISSN: 1478-3223 eISSN: 1478-3231
Armstrong MJ, Hull D, Guo K, Barton D, Hazlehurst JM, Gathercole LL, Nasiri M, Yu JL, Gough SC, Newsome PN, Tomlinson JW, Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
Journal of Hepatology 64 (2) (2015) pp.399-408 ISSN: 0168-8278 eISSN: 1600-0641
Nasiri M, Nikolaou N, Parajes S, Krone NP, Valsamakis G, Mastorakos G, Hughes B, Taylor A, Bujalska IJ, Gathercole LL, Tomlinson JW, 5 alpha-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes
Endocrinology 156 (8) (2015) pp.2863-2871 ISSN: 0013-7227 eISSN: 1945-7170
Woods CP, Corrigan M, Gathercole L, Taylor A, Hughes B, Gaoatswe G, Manolopoulos K, Hogan AE, O’Connell J, Stewart PM, Tomlinson JW, O’Shea D, and Sherlock M, Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT)
The Journal of Clinical Endocrinology & Metabolism 100 (4) (2015) pp.1434-1444 ISSN: 0021-972X eISSN: 1945-7197
Morgan SA, McCabe EL, Gathercole LL, Hassan-Smith ZK, Larner DP, Bujalska IJ, Stewart PM, Tomlinson JW, Lavery GG, 11 beta-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess
Proceedings of the National Academy of Sciences 111 (24) (2014) pp.E2482-E2491 ISSN: 0027-8424 eISSN: 1091-6490
McNelis JC, Manolopoulos KN, Gathercole LL, Bujalska IJ, Stewart PM, Tomlinson JW, Arlt W, Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake
Endocrinology and Metabolism 305 (9) (2013) pp.E1134-E1144 ISSN: 0193-1849 eISSN: 1522-1555
Morgan SA, Gathercole LL, Simonet C, Hassan-Smith ZK, Bujalska I, Guest P, Abrahams L, Smith DM, Stewart PM, Lavery GG, Tomlinson JW, Regulation of Lipid Metabolism by Glucocorticoids and 11 beta-HSD1 in Skeletal Muscle
Endocrinology 154 (7) (2013) pp.2374-2384 ISSN: 0013-7227 eISSN: 1945-7170
Hazlehurst JM, Gathercole LL, Nasiri M, Armstrong MJ, Borrows S, Yu JL, Wagenmakers AJM, Stewart PM, Tomlinson JW, Glucocorticoids Fail to Cause Insulin Resistance in Human Subcutaneous Adipose Tissue In Vivo
The Journal of Clinical Endocrinology & Metabolism 98 (4) (2013) pp.1631-1640 ISSN: 0021-972X eISSN: 1945-7197
Lavery GG, Zielinska AE, Gathercole LL, Hughes B, Semjonous N, Guest P, Saqib K, Sherlock M, Reynolds G, Morgan SA, Tomlinson JW, Walker EA, Rabbitt EH, Stewart PM, Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11 beta-Hydroxysteroid Dehydrogenase Type 1
Endocrinology 153 (7) (2012) pp.3236-3248 ISSN: 0013-7227 eISSN: 1945-7170
McGee KC, Shahmanesh M, Boothby M, Nightingale P, Gathercole LL, Tripathi G, Harte AL, Shojaee-Moradie F, Umpleby AM, Das S, Al-Daghri NM, McTernan PG, Tomlinson JW, Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones
Antiviral Therapy 17 (2012) pp.495-507 ISSN: 1359-6535 eISSN: 2040-2058
Gathercole LL, Morgan SA, Bujalska IJ, Hauton D, Stewart PM, Tomlinson JW, Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue
PLoS ONE 6 (10) (2011) ISSN: 1932-6203 eISSN: 1932-6203
Gathercole LL, Morgan SA, Bujalska IJ, Stewart PM, Tomlinson JW, Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue
Nutrition and Diabetes 1 (2011) ISSN: 2044-4052 eISSN: 2044-4052
Gathercole LL, Stewart PM, Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
The Journal of Steroid Biochemistry and Molecular Biology 122 (1-3) (2010) pp.21-27 ISSN: 0960-0760 eISSN: 1879-1220
Tomlinson JW, Durrani OM, Bujalska IJ, Gathercole LL, Tomlins PJ, Reuser TTQ, Rose GE, Curnow SJ, Stewart PM, Walker EA, Rauz S, The Role of 11 beta-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy
The Journal of Clinical Endocrinology & Metabolism 95 (1) (2010) pp.398-406 ISSN: 0021-972X eISSN: 1945-7197
Morgan SA, Sherlock M, Gathercole LL, Lavery GG, Lenaghan C, Bujalska IJ, Laber D, Yu A, Convey G, Mayers R, Hegyi K, Sethi JK, Stewart PM, Smith DM, Tomlinson JW, 11 beta-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
Diabetes 58 (11) (2009) pp.2506-2515 ISSN: 0012-1797 eISSN: 1939-327X
Boothby M, McGee KC, Tomlinson JW, Gathercole LL, McTernan PG, Shojaee-Moradie F, Umpleby AM, Nightingale P, Shahmanesh M, Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months
Antiviral Therapy 14 (2009) pp.1089-1100 ISSN: 1359-6535 eISSN: 2040-2058
Bujalska IJ, Gathercole LL, Tomlinson JW, Darimont C, Ermolieff J, Fanjul AN, Rejto PA, Stewart PM, A novel selective 11 beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
Journal of Endocrinology 197 (2008) pp.297-307 ISSN: 0022-0795 eISSN: 1479-6805
Gathercole LL, Bujalska IJ, Stewart PM, Tomlinson JW, Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue
The Journal of Clinical Endocrinology & Metabolism 92 (11) (2007) pp.4332-4339 ISSN: 0021-972X eISSN: 1945-7197
Wattier RAM, Gathercole LL, Assinder SJ, Gliddon CJ, Deahl KL, Shaw DS, Mills DI, Sequence variation of intergenic mitochondrial DNA spacers (mtDNA-IGS) of Phytophthora infestans (Oomycetes) and related species
Molecular Ecology Resources 3 (1) (2003) pp.136-138 ISSN: 1755-098X eISSN: 1755-0998

Gathercole LL, Morgan SA, Tomlinson JW, Hormonal Regulation of Lipogenesis
in Litwack G (ed.), Hormonal Regulation of Lipogenesis, Academic Press, Inc. (2013) ISSN: 0083-6729 ISBN: 978-0-12-407766-9

Shahmanesh M, Das S, Boothby M, Mcgee KC, Gathercole LL, Harte AL, Higgins P, Kusminski CM, McTernan PG, Ross J, Tomlinson JW, Complications of HIV Disease or Treatment,
(2010)

Dr Laura Gathercole

Research

Groups

Publications

Journal articles