Dr Korneel Hens
Senior Research Fellow
School of Biological and Medical Sciences
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Research
Groups
Projects as Principal Investigator, or Lead Academic if project is led by another Institution
- TFTag: A novel library of tagged transcription factors in Drosophila (01/12/2022 - 30/11/2027), funded by: Biotechnology & Biological Sciences Research Council (BBSRC), funding amount received by Brookes: £1,144,262
Publications
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Journal articles
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Whitla R, Hens K, Hogan J, Martin G, Breuker C, Shreeve TG, Arif S, The last days of Aporia crataegi (L.) in Britain: Evaluating genomic erosion in an extirpated butterfly
Molecular Ecology 33 (19) (2024) ISSN: 0962-1083 eISSN: 1365-294X The last days of Aporia crataegi (L.) in Britain: Evaluating genomic erosion in an extirpated butterfly Open Access version on RADAR -
Winant M, Buhler K, Clements J, De Groef S, Hens K, Vulsteke V, Callaerts P, Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells
PLoS Genetics 18 (9) (2022) ISSN: 1553-7390 eISSN: 1553-7404 Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells Open Access version on RADAR -
Lopes MR, Parisot N, Gaget K, Huygens C, Peignier S, Duport G, Orlans J, Charles H, Baatsen P, Jousselin E, Da Silva P, Hens K, Callaerts P, Calevro F, Evolutionary novelty in the apoptotic pathway of aphids
Proceedings of the National Academy of Sciences 117 (51) (2020) pp.32545-32556 ISSN: 0027-8424 eISSN: 1091-6490 Evolutionary novelty in the apoptotic pathway of aphids Open Access version on RADAR -
Shokri L, Inukai S, Hafner A, Weinand K, Hens K, Vedenko A, Gisselbrecht SS, Dainese R, Bischof J, Furger E, Feuz JD, Basler K, Deplancke B, Bulyk ML, A Comprehensive Drosophila melanogaster Transcription Factor Interactome.
Cell Reports 27 (3) (2019) pp.955-970.E7 ISSN: 2211-1247 eISSN: 2211-1247 -
Prasad N, Hens K, Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface
Cell Reports 24 (12) (2018) pp.3194-3206 ISSN: 2211-1247 eISSN: 2211-1247 -
Houtz P, Bonfini A, Liu X, Revah J, Guillou A, Poidevin M, Hens K, Huang H, Deplancke B, Tsai Y, Buchon N, Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection
PLoS Genetics 13 (11) (2017) ISSN: 1553-7390 eISSN: 1553-7404 -
Mendoza-García P, Hugosson F, Fallah M, Higgins ML, Iwasaki Y, Pfeifer K, Wolfstetter G, Varshney G, Popichenko D, Gergen JP, Hens K, Deplancke B, Palmer RH, The Zic family homologue Odd-paired regulates Alk expression in Drosophila
PLoS Genetics 13 (4) (2017) ISSN: 1553-7390 eISSN: 1553-7404 -
Herteleer L, Zwarts L, Hens K, Forero D, Del-Favero J, Callaerts P, Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila
Psychopharmacology 233 (9) (2016) pp.1751-1762 ISSN: 0033-3158 -
Nitta KR, Jolma A, Yin Y, Morgunova E, Kivioja T, Akhtar J, Hens K, Toivonen J, Deplancke B, Furlong EE, Taipale J, Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
eLife 4 (2015) ISSN: 2050-084X -
Schertel C, Albarca M, Rockel-Bauer C, Kelley NW, Bischof J, Hens K, van Nimwegen E, Basler K, Deplancke B, A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development.
Genome Research 25 (2015) pp.514-523 ISSN: 1088-9051 eISSN: 1549-5469 -
Sitnik JL, Francis C, Hens K, Huybrechts R, Wolfner MF, Callaerts P, Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila
Genetics 196 (3) (2014) pp.781-797 ISSN: 0016-6731 -
Gubelmann C, Waszak SM, Isakova A, Holcombe W, Hens K, Iagovitina A, Feuz JD, Raghav SK, Simicevic J, Deplancke B, A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks.
Molecular Systems Biology 9 (1) (2013) ISSN: 1744-4292 -
Rockel S, Geertz M, Hens K, Deplancke B, Maerkl SJ, iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks
Nucleic Acids Research 41 (4) (2013) ISSN: 0305-1048 eISSN: 1362-4962 -
Massouras A, Waszak SM, Albarca-Aguilera M, Hens K, Holcombe W, Ayroles JF, Dermitzakis ET, Stone EA, Jensen JD, Mackay TF, Deplancke B, Genomic variation and its impact on gene expression in Drosophila melanogaster
PLoS Genetics 8 (11) (2012) ISSN: 1553-7390 eISSN: 1553-7404 -
Schröter C, Ares S, Morelli LG, Isakova A, Hens K, Soroldoni D, Gajewski M, Jülicher F, Maerkl SJ, Deplancke B, Oates AC, Topology and dynamics of the zebrafish segmentation clock core circuit
PLoS Biology 10 (7) (2012) ISSN: 1544-9173 -
Hens K, Feuz JD, Deplancke B, A high-throughput gateway-compatible yeast one-hybrid screen to detect protein-DNA interactions
Methods in Molecular Biology 786 (2012) pp.335-355 ISSN: 1064-3745 -
Hens K, Feuz JD, Isakova A, Iagovitina A, Massouras A, Bryois J, Callaerts P, Celniker SE, Deplancke B, Automated protein-DNA interaction screening of Drosophila regulatory elements
Nature Methods 8 (2011) pp.1065-1070 ISSN: 1548-7091 eISSN: 1548-7105 -
Gubelmann C, Gattiker A, Massouras A, Hens K, David F, Decouttere F, Rougemont J, Deplancke B, GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR
Database: The Journal of Biological Databases and Curation 2011 (2011) ISSN: 1758-0463 eISSN: 1758-0463 -
Massouras A, Decouttere F, Hens K, Deplancke B, WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data
Nucleic Acids Research 38 (S2) (2010) pp.W378-W384 ISSN: 0305-1048 eISSN: 1362-4962 -
Massouras A, Hens K, Gubelmann C, Uplekar S, Decouttere F, Rougemont J, Cole ST, Deplancke B, Primer-initiated sequence synthesis to detect and assemble structural variants
Nature Methods 7 (2010) pp.485-486 ISSN: 1548-7091 eISSN: 1548-7105 -
Clements J, Hens K, Merugu S, Dichtl B, de Couet HG, Callaerts P, Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila
Developmental Biology 334 (2) (2009) pp.503-512 ISSN: 0012-1606 -
Clements J, Hens K, Francis C, Schellens A, Callaerts P, Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons
Proceedings of the National Academy of Sciences 105 (42) (2008) pp.16183-16188 ISSN: 0027-8424 eISSN: 1091-6490 -
Callaerts P, Clements J, Francis C, Hens K, Pax6 and eye development in Arthropoda
Arthropod Structure & Development 35 (4) (2006) pp.379-391 ISSN: 1467-8039 -
Hens K, Lemey P, Macours N, Francis C, Huybrechts R, Cyclorraphan yolk proteins and lepidopteran minor yolk proteins originate from two unrelated lipase families
Insect Molecular Biology 13 (6) (2004) pp.615-623 ISSN: 0962-1075 eISSN: 1365-2583 -
Macours N, Poels J, Hens K, Francis C, Huybrechts R, Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes
International Review of Cytology 239 (2004) pp.47-97 ISSN: 0074-7696 -
Hens K, Macours N, Claeys I, Francis C, Huybrechts R, Cloning and expression of the yolk protein of the tsetse fly Glossina morsitans morsitans
Insect Biochemistry and Molecular Biology 34 (12) (2004) pp.1281-1287 ISSN: 0965-1748 -
Deloffre L, Sautiere PE, Huybrechts R, Hens K, Vieau D, Salzet M, Angiotensin-converting enzyme inhibition studies by natural leech inhibitors by capillary electrophoresis and competition assay
European Journal of Biochemistry 271 (11) (2004) pp.2101-2106 ISSN: 0014-2956 eISSN: 1432-1033 -
Macours N, Hens K, Zinc-metalloproteases in insects: ACE and ECE
Insect Biochemistry and Molecular Biology 34 (6) (2004) pp.501-510 ISSN: 0965-1748 -
Macours N, Hens K, Francis C, De Loof A, Huybrechts R, Molecular evidence for the expression of angiotensin converting enzyme in hemocytes of Locusta migratoria: stimulation by bacterial lipopolysaccharide challenge
Journal of Insect Physiology 49 (8) (2003) pp.739-746 ISSN: 0022-1910 eISSN: 1879-1611 -
Macours N, Poels J, Hens K, Luciani N, De Loof A, Huybrechts R, An endothelin-converting enzyme homologue in the locust, Locusta migratoria: functional activity, molecular cloning and tissue distribution
Insect Molecular Biology 12 (3) (2003) pp.233-240 ISSN: 0962-1075 eISSN: 1365-2583 -
Rahman MM, Bosch LV, Baggerman G, Clynen E, Hens K, Hoste B, Meylaers K, Vercammen T, Schoofs, De Loof A, Breuer M, Search for peptidic molecular markers in hemolymph of crowd-(gregarious) and isolated-reared (solitary) desert locusts, Schistocerca gregaria
Peptides 23 (11) (2002) pp.1907-1914 ISSN: 0196-9781 eISSN: 1873-5169 -
Vandingenen A, Hens K, Baggerman G, Macours N, Schoofs L, De Loof A, Huybrechts R, Isolation and characterization of an angiotensin converting enzyme substrate from vitellogenic ovaries of Neobellieria bullata
Peptides 23 (10) (2002) pp.1853-1863 ISSN: 0196-9781 eISSN: 1873-5169 -
Hens K, Vandingenen A, Macours N, Baggerman G, Karaoglanovic AC, Schoofs L, De Loof A, Huybrechts R, Characterization of four substrates emphasizes kinetic similarity between insect and human C-domain angiotensin-converting enzyme
European Journal of Biochemistry 269 (14) (2002) pp.3522-3530 ISSN: 0014-2956 eISSN: 1432-1033 -
Baggerman G, Huybrechts J, Clynen E, Hens K, Harthoorn L, Van der Horst D, Poulos C, De Loof A, Schoofs L, New insights in Adipokinetic Hormone (AKH) precursor processing in Locusta migratoria obtained by capillary liquid chromatography-tandem mass spectrometry
Peptides 23 (4) (2002) pp.635-644 ISSN: 0196-9781 eISSN: 1873-5169 -
Vandingenen A, Hens K, Macours N, Schoofs L, De Loof A, Huybrechts R, Presence of angiotensin converting enzyme (ACE) interactive factors in ovaries of the grey fleshfly Neobellieria bullata
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 132 (1) (2002) pp.27-35 ISSN: 1096-4959 eISSN: 1879-1107 -
Vandingenen A, Hens K, Macours N, Zhu W, Janssen I, Breuer M, De Loof A, Huybrechts R, Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshfly Neobellieria bullata
Archives of Insect Biochemistry and Physiology 47 (3) (2001) pp.161-167 ISSN: 0739-4462 eISSN: 1520-6327
Other publications
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Winant M, Buhler K, Clements J, De Groef S, Hens K, Vulsteke V, Callaerts P, Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in <i>Drosophila</i> Insulin-Producing cells
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(2022)